<i>In Vivo</i> Transcriptome of Lactobacillus acidophilus and Colonization Impact on Murine Host Intestinal Gene Expression

To date, our basis for comprehending the probiotic mechanisms of Lactobacillus acidophilus , one most widely consumed microbes, was largely limited to in vitro functional genomic studies. Using a germfree murine colonization model, vivo -based transcriptional studies provided first view how L. survives mammalian gut environment, including gene expression patterns linked survival, efficient nutrient acquisition, stress adaptation, and host interactions.